Pathophysiology of Peripheral Neuropathy

nerve damage on hand

Peripheral neuropathy encompasses a diverse group of disorders characterized by damage to peripheral nerves, resulting in sensory, motor, and autonomic dysfunction. Etiologies include diabetic neuropathy, post-traumatic nerve injury, chemotherapy-induced neuropathy, and idiopathic conditions. Pathophysiologic mechanisms involve axonal degeneration, demyelination, microvascular compromise, and abnormal excitability of peripheral neurons. Chronic neuropathic pain arises from both peripheral sensitization […]

Mechanisms of Peripheral Nerve Stimulation in Pain Modulation

electrical nerve stimulation

Peripheral nerve stimulation (PNS) is an innovative neuromodulatory technique that targets specific peripheral nerves to alleviate localized musculoskeletal pain. The procedure involves percutaneous implantation of leads adjacent to the affected nerve, delivering low-intensity electrical impulses that modulate nociceptive transmission. By influencing both afferent and central pain pathways, PNS can alter the perception of pain and […]

Neuropathy Without Nerves: Why Some Pain Feels Real Even When Tests Are Normal

By Dr. Nikesh Seth Pain is a deeply personal experience. For many patients, it is tied to a clear physical finding such as a herniated disc, joint degeneration, or nerve compression. For others, the source of discomfort is far less obvious. Neuropathy, or nerve related pain, can present in ways that standard tests may not […]

The Role of Family Support in Pain Recovery: Why It Matters More Than You Think

By Dr. Nikesh Seth Chronic pain is rarely an isolated experience. It affects not only the body, but also the mind, emotions, and daily routines. For patients in Scottsdale, Phoenix, and surrounding communities, recovery is most successful when it is supported by a network of family and loved ones. Family involvement is often the overlooked […]