Pathophysiology of Peripheral Neuropathy
Peripheral neuropathy encompasses a diverse group of disorders characterized by damage to peripheral nerves, resulting in sensory, motor, and autonomic dysfunction. Etiologies include diabetic neuropathy, post-traumatic nerve injury, chemotherapy-induced neuropathy, and idiopathic conditions. Pathophysiologic mechanisms involve axonal degeneration, demyelination, microvascular compromise, and abnormal excitability of peripheral neurons. Chronic neuropathic pain arises from both peripheral sensitization […]
Mechanisms of Peripheral Nerve Stimulation in Pain Modulation
Peripheral nerve stimulation (PNS) is an innovative neuromodulatory technique that targets specific peripheral nerves to alleviate localized musculoskeletal pain. The procedure involves percutaneous implantation of leads adjacent to the affected nerve, delivering low-intensity electrical impulses that modulate nociceptive transmission. By influencing both afferent and central pain pathways, PNS can alter the perception of pain and […]